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Clinical features: The symptoms of overdosage are likely to be an extension of vinblastine's pharmacological action. Possible symptoms of toxicity are those listed under Adverse Reactions.
The major effect of toxic doses of DBL Vinblastine Injection will be myelosuppression and this may be life threatening.
Management: Symptomatic supportive measures should be instituted. Particular attention should be given to prevention and treatment of possible severe infections secondary to severe, persistent bone marrow depression. Specialist texts should be consulted.
